CareLit Fachartikel
Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 gene (MRP2/ABCC2) with susceptibility to bile duct cancer
A Höblinger, F Grünhage, T Sauerbruch, F Lammert · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Dokument
1041908
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Aims: Multidrug resistance protein 2 (MRP2/ABCC2) is one of the ATP-binding cassette transporters expressed on the apical membrane of hepatocytes and cholangiocytes. ABCC2 plays an important role in the biliary clearance of a wide variety of endogenous and exogenous toxic compounds. In a recent study, the c.3972 C>T (I1324I) variant in exon 28 was significantly associated with hepatocellular carcinoma risk (Meyer-Heithuis et al. Z Gastroenterol 2004; 42:931). The aim of this study was to assess the role of this ABCC2 variant on cholangiocarcinoma susceptibility. Methods: Prospectively, we recruited 60 cholangioc…
Schlagworte
Cholangiocarcinoma
Association
Allele
ATP-Binding Cassette Transporters
Observation
Zeitschrift für Gastroenterologie
