The influence of FAAH (Fatty Acid Hydrolase) expression and FAAH C/A (p.Pro129Thr; rs324420) single nucleotide polymorphism in patients with inflammatory bowel disease
B Yüce, D Emmerdinger, J Diegelmann, S Pfennig, T Ochsenkühn, B Göke, P Lohse, M Storr, S Brand · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: The endocannabinoid systems seems to play a crucial role in intestinal inflammation. Our aim was to analyze FAAH expression and the role of the FAAH 385 C/A (p.Pro129Thr; rs324420) single nucleotide polymorphism (SNP) in patients with Crohn's disease (CD) and ulcerative colitis (UC). Methods and Patients: In inflamed an non inflamed CD lesions and intestinal epithelial cells (IECs) FAAH mRNA expression after stimulation with proinflammatory cytokines. In genomic DNA of 1008 individuals who could be divided into CD n=435, UC n=167; controls n=406 FAAH 385 C/A SNP could be analyzed by restriction fragment le…
