CareLit Fachartikel
The Role of Her-2 in the Carcinogenesis of Breast Cancer – When and Where?
J Rüschoff · Geburtshilfe und Frauenheilkunde · 2009 · Heft 02
Dokument
1042209
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Her2 characterizes a distinct breast cancer progression pathway In breast carcinomas overexpression and amplification of ErbB2/Her2/neu gene has been shown to be of prognostic value, leading to the identification of the oncoprotein as a target for therapeutic strategies, such as the inhibition by trastuzumab (Herceptin). However, the molecular mechanisms underlying Her2 action in breast cancer and its role in the development of breast carcinoma is still incompletely understood. As in colon cancer a linear model of BC development was favored (Burstein et al. NEJM 350:1430–41, 2004) with hyperplasia, ductal carcin…
Schlagworte
Breast
Carcinoma in Situ
Apoptosis
Population
Actin
After
Tumor
Geburtshilfe und Frauenheilkunde
