CareLit Fachartikel
Pharmakokinetische Probleme in der Praxis
D Rosskopf, H K Kroemer, W Siegmund · DMW - Deutsche Medizinische Wochenschrift · 2009 · Heft 08 · S. 345-356
Dokument
1042219
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Summary Drug disposition is controlled by drug metabolism and drug transport. In the last decade numerous drug transporters have been identified and characterized in the context of drug uptake, efflux and interactions. This article reviews major advancements in this field. Efflux pumps like the multidrug resistance protein 1 (MDR1, ABCB1) are expressed in the intestine where they secrete drugs back into the intestinal lumen. Inhibitors of ABCB1 can increase the bioavailability of such drugs due to an increased absorption. Inducers of metabolism (rifampicin, carbamazepine, St. John’s Wort) also induce the express…
Schlagworte
Arzneimittelinteraktionen
Arzneimitteltransporter
Arzneimittelmetabolismus
CYP-Enzyme
ABC-Transporter
SLCO1B1
drug interactions
drug transport
drug metabolism
CYP enzymes
Absorption
Carbamazepine
Lead
DMW - Deutsche Medizinische Wochenschrift
