CareLit Fachartikel
Expression of smooth muscle cell markers in activated hepatic stellate cells is connected to MAP kinase regulated transcription levels of serum response factor (SRF)
J Herrmann, U Haas, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2009 · Heft 01
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1042275
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Jahr
2009
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Zusammenfassung
Activation of hepatic stellate cells (HSC) is a major event in liver fibrogenesis. A typical feature of activated HSC is the expression of α-smooth muscle actin (SMA) and other smooth muscle cell (SMC) marker genes. The transcription of these genes is mainly regulated by the transcription factor ‘serum response factor’ (SRF) [1]. Less is known about transcriptional control of the SRF gene itself. We could recently demonstrate that TGF-β upregulates SRF in activated HSC [2]. Primary rat HSC or CFSC were treated with specific inhibitors against the ALK5 receptor and members of the MAPK pathways (ERK, JNK, p38). Th…
Schlagworte
HSC
MAPK
alpha-SMA
fibrogenesis
gene regulation
liver
serum response factor
Dexamethasone
Actin
After
Zeitschrift für Gastroenterologie
