A hepatocyte nuclear factor-3 site in ALR promoter is important for interleukin 6-induced expression
R Dayoub, T Dobner, P Groitl, WE Thasler, C Hellerbrand, AK Bosserhoff, HJ Schlitt, TS Weiss · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Liver regeneration is an important survival process that occurs after liver injury e.g. viral infection, toxins or hepatectomy. This process involves a variety of specific cytokines, growth factors and transcription factors. In the liver, hepatocyte nuclear factors (HNFs) play a central role during liver regeneration. These include the HNF3 transcription factors, also termed forkhead box (Fox) family. Additionally, it has been shown that Foxa2 (HNF-3β) expression is induced in regenerating mouse livers after partial hepatectomy as well as in livers from patients with hepatocellular carcinoma HCC. Furthermore, we…
