The hepatitis C virus non-structural 3/4A protease activates Akt-dependent host cell signaling which is required for sufficient viral replication
ED Brenndörfer, J Karthe, P Cebula, A Erhardt, L Frelin, J Schulte am Esch, D Häussinger, JG Bode, M Sällberg · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
The hepatitis C virus (HCV) interferes with several cellular signaling pathways to warrant viral replication as well as survival of the infected cell and to protect the infected cell from antiviral efector mechanisms of the host. Thus it counteracts the interferon response to viral infection through non-structural 3/4A (NS3/4A) protease-mediated cleavage of CARDIF and TRIF thereby interrupting an important part of the innate antviral host response. The present study aimed to further clarify the interaction between NS3/4A and growth factor signaling of the host cell and its contribution to viral replication. We r…
