Safety, tolerability and efficacy of linezolid in the treatment of MDR- and XDR-TB. A TBNET survey
BM Giovanni, B Eker, M Richardson, G Sotgiu, J Zellweger, A Skrahina, J Ortmann, E Girardi, H Hoffmann, G Besozzi, R Centis · Pneumologie · 2009 · Heft 03
Bibliografische Angaben
Zusammenfassung
Aims: Antibiotic resistance of Mycobacterium tuberculosis is an emerging problem in the fight against tuberculosis. Linezolid-containing multi-drug-regimen have been suggested for the treatment of complicated cases of MDR/XDR-TB, however, clinical data on the safety, tolerability and efficacy of linezolid in the treatment against tuberculosis are lacking. Methods: We performed a retrospective, multi-center, observational cohort study with a nested case-control study at different centers in four European countries to evaluate the safety and tolerability of linezolid at 600mg once (OD) or twice daily (BD) in the t…
