Serum-based diagnosis and mouse models for preeclampsia

The overarching goal of this study is to use serum as a blueprint to establish in vivo and in vitro diagnostic and treatment models for pregnancy disorders such as preeclampsia and intrauterine growth restriction (IUGR). When combined, preeclampsia and IUGR complicate 10–15% of all pregnancies worldwide and are a major cause of maternal, fetal and neonatal mortality and morbidity. Despite intense investigation, these complications have remained enigmatic and the mechanisms that contribute to their emergence are largely unknown. We have recently initiated serum-based studies to establish in vitro and in vivo pred…