Circulating RBP4 is associated with obesity related glucose and lipid metabolism alterations in children and adolescents
D Friebe, M Neef, S Erbs, R Ketzscher, J Kratzsch, P Kovacs, M Blüher, W Kiess, A Körner · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Retinol binding protein 4 (RBP4) was proposed as novel adipokine that potentially links obesity, insulin resistance and cardiovascular complications. In this study, we applied experimental, clinical and genetic approaches to investigate associations of RBP4 with obesity, insulin resistance and vascular alterations in children and adolescents. We recruited 62 obese (age 11.9±0.3 years, BMI-SDS 2.26±0.06) and 69 healthy lean children and adolescents (age 12.3±0.4 years, BMI-SDS -0.28±0.09). To identify a potential relation of RBP4 with normal, physical development, we analysed circulating RBP4 levels in dependence…
