Activated protein C signaling via protease activated receptor-3 protects against glucose induced podocyte apoptosis
M Thati, H Wang, I Vinnikov, M Kashif, K Shahzad, V Schwenger, PP Nawroth, B Isermann · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Activated protein C (APC) exerts anti-coagulant, anti-inflammatory and anti-apoptotic activities. We have recently shown that APC modulates diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. The cyto-protective effects of APC on endothelial cells require endothelial protein C receptor (EPCR) and protease activated receptor-1 (PAR-1). However, it is not known how APC regulates podocyte function. Expression of coagulation regulators, receptors and signalling intermediates was determined by RT-PCR and immunoblotting in immortalized differentiated human podocytes. Apoptosis in podocytes was analy…
