Genome wide association study for lipid traits in the self-contained population of sorbs in Germany
A Tönjes, J Dünnebeil, D Schleinitz, M Koriath, NW Rayner, K Dietrich, B Enigk, Y Böttcher, K Krohn, P Kovacs, M Stumvoll · Diabetologie und Stoffwechsel · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objects: Recently, association of a number of common genetic variants with lipid traits has been reported in different populations. We performed a genome wide association (GWA) study in a self-contained population from Eastern Germany, the Sorbs. Material and methods: We used linear regression analyses to calculate the effects of ˜390K single nucleotide polymorphisms (SNPs) (Affymetrix gene arrays) on LDL-cholesterol (LDL), HDL-cholesterol (HDL) and triglyceride levels (TG) in 825 subjects. Furthermore, we used two publicly available databases for “in-silico“ replication (Diabetes Genetics Initiative for LDL, HD…
