CareLit Fachartikel

MicroRNAs contribute to the leukemogenic effect of MLL-AF9

KK Fleischmann, J von Frowein, T Magg, P Pagel, M Albert, I Schmid, AA Roscher · Klinische Pädiatrie · 2009 · Heft 05

Dokument
1042698
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
KK Fleischmann, J von Frowein, T Magg, P Pagel, M Albert, I Schmid, AA Roscher
Ausgabe
Heft 05 / 2009
Seiten
–
Erschienen: 2009-05-11 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0029-1222635

Zusammenfassung

Aims: The translocation t(9;11) (p22;q23) is frequent in acute myeloid leukemia (AML M5). It leads to the expression of the fusion-gene and -protein MLL-AF9, which has a proven leukemogenic effect whereas it's mechanism of leukemogenesis is largely unknown. MicroRNAs (miRNAs) are potent regulators of gene expression and are widely involved in the development of cancer. We hypothesized that at least part of the leukemogenic effect of MLL-AF9 is mediated by deregulated miRNA expression. Method: We generated a specific knock-down of the fusion gene MLL-AF9 via siRNA in the AML-M5 cell line THP1 and analyzed changes…

Schlagworte

Apoptosis Klinische Pädiatrie