LSD1 is a Potential Therapeutic Target in Medulloblastoma
K Pajtler, T Thor, L Oles, M Baumann, LC Heukamp, R Büttner, J Kirfel, A Schramm, A Eggert, JH Schulte · Klinische Pädiatrie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
The importance of epigenetic gene regulation has been established in medulloblastoma for both DNA methylation and histone acetylation. Histone methylation has long been considered to be irreversible and less versatile. With the recent discovery of the first histone demethylase, lysine desaminase 1 (LSD1), this paradigm has been overcome. Taken into consideration the high expression and functional importance of LSD1 in various other tumor types, including neuroblastoma (Schulte et al., Cancer Res 2009), we analysed the expression and functional implication of LSD1 in medulloblastoma. Re-analysis of microarray dat…
