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Expression analysis of 93 selected genes for prediction of treatment response in childhood acute lymphoblastic leukemia (ALL)

R Romey, M Stanulla, R Häsler, S Schreiber, M Zimmermann, M Schrappe, G Cario · Klinische Pädiatrie · 2009 · Heft 05

Dokument
1042702
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
R Romey, M Stanulla, R Häsler, S Schreiber, M Zimmermann, M Schrappe, G Cario
Ausgabe
Heft 05 / 2009
Seiten
–
Erschienen: 2009-05-11 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0029-1222675

Zusammenfassung

In trial ALL-BFM 2000, risk adapted treatment stratification is mainly based on the assessment of in-vivo response to treatment. However, to optimally adjust treatment, identification of resistant patients as early as possible would be desirable. In previous studies we and others showed that distinct gene expression profiles, measured in leukemic cells obtained prior treatment, can predict molecular treatment response and outcome. To validate these findings, we selected 93 genes, 54 from our and 39 from other published studies, and measured the expression of these genes based on qRT-PCR in two representative set…

Schlagworte

Treatment Genes Expression Response Patients All-Bfm Based Resistant Early Studies Measured These Klinische Pädiatrie