CareLit Fachartikel
A universal tool to functionally investigate different MLL fusion proteins
N Spilger, T Dingermann, R Marschalek · Klinische Pädiatrie · 2009 · Heft 05
Dokument
1042703
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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zitierfähig
Bibliografische Angaben
Zusammenfassung
The number of different MLL fusion genes in pediatric and adult acute leukemia patients has dramatically increased in the past years. Sixty-four different MLL fusion are yet characterized at the molcular level, but only the most frequent recombination partners of MLL have been functionally tested by in vitro (replating assays) or in vivo experiments (mouse experiments). Here, we present an universal retroviral vector system that was designed to investigate different MLL fusions. The vector backbone encodes the N-terminal portion of MLL (exons 1–9) which is fused to different fusion partner sequences by a short i…
Schlagworte
Fusion
Vector
Different
Vitro
Experiments
Partner
Universal
Retroviral
Backbone
Fused
Frame
Pentry
Klinische Pädiatrie
