The negative role of insulin resistance for sustained virological response in chronic hepatitis C patients

Background: The response to pegylated interferon (PEG-IFN) and ribavirin (RBV) treatment in chronic hepatitis C (CHC) is influenced by various factors. Insulin resistance (IR), hepatic steatosis and overweight are associated with poor results. Aim: to analyze the association between the parameters of IR and the response to the antiviral treatment in CHC patients. Patients and methods: 87 CHC patients (37 male, M/50 female, F; each genotype 1), mean age 46.8 (18–65) years were involved into the study. 19 patients had type 2 diabetes mellitus. Body weight, BMI (body mass index), waist circumference, HOMA (homeosta…