In vitro and in vivo analysis of the role of Alpha-2 adrenoceptors in the regulation of gastric motility in the rat

Activation of presynaptic α2-adrenergic receptors has been known to mediate several functions of the G.I. tract. They inhibit gastrointestinal motility, gastric acid secretion and induce gastric mucosal protection. Aim: To study the effect of clonidine, oxymetazoline (α2A-adrenoceptor agonist) and ST-91 (α2B/C-adrenoceptor agonist) on electrical field stimulation (EFS)-induced contraction of isolated rat gastric fundus stripe in vitro and on insulin-induced stimulated gastric contractions in vivo. Methods: 1. Male Wistar rats (250–350g) were killed, their stomachs were removed and 3–4cm long stripes of the fundu…