Acute phase reactants in patients with Wilson's disease

Background: Wilson's disease (WD) is a rare disorder of copper metabolism frequently associated with hepatic involvement leading to liver cirrhosis. Serum concentration of the negative acute phase reactant human fetuin A/α2HS-glycoprotein (AHSG) is a good predictor of mortality due to liver failure in patients with alcoholic cirrhosis. Our aim was to study the AHSG and another acute phase reactant in WD with special respect to liver cirrhosis. Patients and methods: Serum concentrations of positive (α1-acid glycoprotein/orosomucoid, OROSO) and negative (AHSG) acute phase reactants were studied in 50 patients with…