MR spectroscopy changes and neuropsychometric deficits in patients with renal insufficiency
AB Tryc, G Alwan, M Bokemeyer, A Goldbecker, M Haubitz, K Weissenborn · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction: Uremic encephalopathy is normally diagnosed by neurological deficits in patients with chronic renal insufficiency. However, neuropsychological deficits may occur long before any overt neurological symptoms can be observed. Little is known about the underlying brain pathology of patients suffering from uremic encephalopathy. We hypothesized that cognitive deficits present in patients with renal insufficiency treated with and without hemodialysis may correspond to neurometabolite changes in distinct brain regions. Methods: We performed MR-spectrometry in 23 non-dialyzed patients with chronic renal in…