Prophylactic levetiracetam perioperatively in neurosurgery
KM Schebesch, J Schlaier, A Brawanski, M Lange · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Objective: To evaluate the prophylactic anticonvulsant use of levetiracetam in craniotomy-patients with contraindications for phenytoin. The prophylactic use of anticonvulsants in Neurosurgery is controversial because the evidence is inconsistent. Phenytoin is the only approved agent for this indication, but it can cause critical drops in blood pressure and heart rate. Therefore the routine prophylactic use of phenytoin for craniotomies needs careful consideration especially in cardiologically compromised patients. Hence, newer antiepileptic drugs (AEDs) with fewer adverse reactions have been recommended for thi…