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Brain-derived neurotrophic factor gene polymorphisms shape cortical plasticity in humans

L Chaieb, V Moliadze, K Monte-Silva, C Poreisz, N Thirugnanasambandam, MA Nitsche, M Shoukier, H Ludwig, W Paulus, A Antal · Aktuelle Neurologie · 2009 · Heft 10

Dokument
1043034
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Jahr
2009
Publikation
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DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
L Chaieb, V Moliadze, K Monte-Silva, C Poreisz, N Thirugnanasambandam, MA Nitsche, M Shoukier, H Ludwig, W Paulus, A Antal
Ausgabe
Heft 10 / 2009
Seiten
–
Erschienen: 2009-10-07 00:00:00
ISSN
0302-4350
DOI
10.1055/s-0029-1238645

Zusammenfassung

The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the adult brain. Recently it has been demonstrated that BDNF also plays a significant role in shaping externally induced human brain plasticity. Plasticity induced in the human motor cortex by intermittent theta-burst stimulation (iTBS) was impaired in individuals expressing the Val66Met polymorphism. To explore whether this polymorphism is also important for other neuroplasticity-inducing tools in humans with modes of action differing from that of iTBS, namely transcranial direct current (tDCS) and random noise…

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