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„Harm Sign“– without harm? MRI-based blood-brain-barrier leakages without ischaemic lesions in two elderly patients

WUH Schmidt, M Rozanski, GJ Jungehülsing, JB Fiebach · Aktuelle Neurologie · 2009 · Heft 10

Dokument
1043039
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
WUH Schmidt, M Rozanski, GJ Jungehülsing, JB Fiebach
Ausgabe
Heft 10 / 2009
Seiten
–
Erschienen: 2009-10-07 00:00:00
ISSN
0302-4350

Zusammenfassung

Background: Cerebral spinal fluid (CSF) enhancement after gadolinium administration as a marker of blood brain barrier (BBB) disruption has been described for all CNS diseases affecting the vascular integrity. After ischemic stroke the hyperintense acute reperfusion marker or HARM-sign might indicate early blood brain barrier disruption. It was shown to predict both haemorrhagic transformation and a worse clinical outcome. We present two cases of CSF-enhancement two days after hospital admission without acute ischemic pathology in MRI. Methods: Patients were enrolled in the 1000+ study of the Centre for Stroke R…

Schlagworte

After Blood-Brain Barrier Blood Diabetes Mellitus Aphasia Germany Berlin Aktuelle Neurologie