„Harm Sign“– without harm? MRI-based blood-brain-barrier leakages without ischaemic lesions in two elderly patients
WUH Schmidt, M Rozanski, GJ Jungehülsing, JB Fiebach · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Cerebral spinal fluid (CSF) enhancement after gadolinium administration as a marker of blood brain barrier (BBB) disruption has been described for all CNS diseases affecting the vascular integrity. After ischemic stroke the hyperintense acute reperfusion marker or HARM-sign might indicate early blood brain barrier disruption. It was shown to predict both haemorrhagic transformation and a worse clinical outcome. We present two cases of CSF-enhancement two days after hospital admission without acute ischemic pathology in MRI. Methods: Patients were enrolled in the 1000+ study of the Centre for Stroke R…