Genetic variants of folate and methionine metabolism and primary central nervous system lymphoma incidence in a German cohort of 185 patients
D Kurzwelly, S Knop, J Löffler, A Korfel, E Thiel, H Hebart, M Weller, M Linnebank, U Herrlinger · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Objective: Functional genetic polymorphisms of folate and methionine metabolism play an important role in DNA synthesis and methylation, and affect the risk of various cancers including lymphoproliferative disorders. In a retrospective analysis of 185 immunocompetent patients with primary central nervous system lymphoma (PCNSL) and 212 population controls we therefore investigated eight polymorphisms in folate-metabolizing genes for a potential association with the development of PCNSL. Methods: Genotyping was performed by amplification of genomic DNA applying polymerase chain reaction (PCR) and subsequent restr…
