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Independent genetic associations of hepatic fibrosis and hepatocellular carcinoma in both murine reference and human populations

SN Weber, RA Hall, F Lammert, A Teufel · Zeitschrift für Gastroenterologie · 2009 · Heft 09

Dokument
1043200
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
SN Weber, RA Hall, F Lammert, A Teufel
Ausgabe
Heft 09 / 2009
Seiten
–
Erschienen: 2009-09-28 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1241355

Zusammenfassung

Aims: Beside environmental factors, hepatic fibrosis and progression to hepatocellular carcinoma (HCC) might be mediated by common risk genes. Aim: The aim of our study was to assess potential genetic relationships between fibrosis and HCC in mice and humans. Methods: Associations between human genes and liver fibrosis and HCC, respectively, were compiled in the LOGA (Library of Genetic Associations) database (http://www.medicalgenomics.org). For comparison, we analyzed genetic factors that predispose to fibrosis and HCC in a murine reference population. As reference population, we availed of phenotypic and geno…

Schlagworte

Population Database Association After Tumor Zeitschrift für Gastroenterologie