Bile acid levels as a host factor affecting antiviral treatment response but not viral replication in hepatitis C patients
R Iwata, B Stieger, J Mertens, O Goetze, K Sabrane, A Vergopoulos, J Braun, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: The outcome of HCV infection varies among individuals and the likelihood of achieving a SVR to antiviral therapy depends on both viral and host characteristics. Recently, in vitro studies demonstrated that bile acids (BA) upregulate genotype 1 HCV (HCV-1) replication and interfere with IFN effects. Aim of this study was to investigate the influence of BA concentrations and an ABCB11 transporter polymorphism (V444A associated with lower BSEP expression) on viral load and SVR in HCV pts. Methods: N=198 Caucasian HCV pts treated with PEG-IFN/ribavirin were included. 110 Caucasian individuals undergoing liver…
