Potential diagnostic value of serum proteome profiling with MALDI-TOF-MS and the suggested serum markers sFlt-1, PlGF and Endoglin in patients with preeclampsia

Background: Release of circulating factors from the placenta that induce endothelial dysfunction is considered as one of the various causes of preeclampsia. A promising approach to biomarker discovery referring to early diagnosis of preeclampsia is protein profiling using matrix assisted laser desorption/ionisation time of flight mass spectrometry (MALDI-TOF-MS). The aim of this study was to evaluate proteome analysis sFlt-1, PlGF and Endoglin to aid early detection and monitoring the course of preeclampsia. Materials and methods: Serum samples obtained from 29 preeclamptic patients (PE; 27 to 41 week of gestati…