Essential role of NFATc2 in CD8+ T cells in experimental model of asthma
R Karwot, JH Maxeiner, S Schmitt, P Scholtes, K Sauer, M Hausding, A Doganci, HA Lehr, PR Galle, S Finotto · Pneumologie · 2007 · Heft 02
Bibliografische Angaben
Zusammenfassung
The present study demonstrates that mice lacking nuclear factor of activated T cells-2 (NFATc2) developed, in absence of allergen challenge, increased AHR, associated with lung hyperproliferating activated CD4+ Th2 as well as CD8 T cells defective in IFN-gamma production. Moreover, lung effector CD8+ T cells from NFATc2 (-/-) as well as CD8+ T cells from IFN-gamma (-/-) mice contained increased number of CD8+ CD122+ double positive T regulatory cells resulting in increased IL-10 release in their CD8+ T cells compartment compared to those isolated from wild type littermates. In addition, as compared to CD8+NFATc2…
