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The knockout of latent transforming growth factor-β binding protein–1 (LTBP–1) affects the fibrogenic potential in mice liver

F Drews, S Knöbel, A Bosio, C Conrad, M Moser, AM Gressner, R Weiskirchen · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1043716
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
F Drews, S Knöbel, A Bosio, C Conrad, M Moser, AM Gressner, R Weiskirchen
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967765

Zusammenfassung

Aims: Latent transforming growth factor-β binding proteins (LTBP–1, –2, 3-, –4) are glycosylated proteins of the extracellular matrix involved in the secretion and controlling the bioavailability of active transforming growth factor-β (TGF-β). LTBP–1 and TGF-β are key factors in the pathophysiology of liver fibrogenesis. During this process, hepatic stellate cells (HSC) become activated and transdifferentiate into myofibroblasts. Because the knowledge of LTBP functionality in controlling and regulation the concentration of biological active TGF-β is crucial for the understanding of fibrogenesis in the liver we g…

Schlagworte

LTBP TGF-beta signalling bile duct ligation fibrogenesis knock out animal model microarray analysis Bilirubin Blood After Zeitschrift für Gastroenterologie