CareLit Fachartikel

Irradiation leads to apoptosis of Kupffer Cells by a HSP27- dependant pathway followed by release of TNF-alpha

K Tello, H Gürleyen, J Dudas, H Christiansen, F Hess, G Ramadori, B Saile · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1043718
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
K Tello, H Gürleyen, J Dudas, H Christiansen, F Hess, G Ramadori, B Saile
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967785

Zusammenfassung

In our previous publication we were able to show that irradiation of Kupffer cells, the liver resident macrophages, leads to an increased TNF-α- concentration in the culture medium. The pathomechanisms underlying this phenomenon however left to be elucidated. Northern- Blot analysis revealed that TNF-α- gene expression of Kupffer- cells did not change due to irradiation indicating that changes of the TNF-α concentration in the culture medium is regulated on protein level. Following irradiation apoptosis rate increased drastically within 48h. Contemporarily total TNF-α concentration in cell lysates of Kupffer cel…

Schlagworte

Apoptosis Irradiation Kupffer-Cells HSP27 TNF-alpha Observation Zeitschrift für Gastroenterologie