Regulation and function of Fibroblast Growth Factor Receptor 2IIIb (FGFR2IIIb) in hepatocancerogenesis
T Amann, T Spruss, F Bataille, C Liedtke, M Mühlbauer, C Trautwein, A Bosserhoff, C Hellerbrand · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
The b isoform of Fibroblast Growth Factor Receptor 2 (FGFR2IIIb) is highly expressed in hepatocytes and has been shown to play an important role in liver homeostasis and regeneration. Here, we analyzed the expression and function of FGFR2IIIb in hepatocellular carcinoma (HCC). Methods and Results: FGFR2IIIb mRNA expression was downregulated in HCC cell lines compared to primary human hepatocytes as determined by quantitative PCR. Similarly, HCC tissues from patients and animal models (c-myc and IgEGF transgenic mice) showed reduced or lost FGFR2IIIb mRNA expression compared to corresponding non-cancerous liver t…
