Incidence of genetic polymorphisms of the Peroxisome Proliferator-Activated Receptor γ and leptin receptor gene in patients with Non-Alcoholic Fatty Liver Disease
J Rey, B Sandelin, M Scheffler, HU Kasper, G Gerken, A Canbay, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver diseases ranging from simple fatty liver (steatosis), to nonalcoholic steatohepatitis (NASH), to cirrhosis as the irreversible, fibrotic form with advanced scarring of the liver. Peroxisome proliferator-activated receptor γ (PPAR γ) and the leptin receptor are involved in many cellular functions including lipid metabolism, adipogenesis and inflammatory and fibrogenic signaling. Both mediators are expressed in Hepatic Stellate Cells, but whereas the leptin signalling is profibrotic, the PPAR γ acts antifibrogenically. In the present study…
