ALR, a hepatotrophic protein essential for liver regeneration is overexpressed in hepatocellular carcinoma and cirrhosis
H Wagner, H Wagner, W Thasler, F Bataille, A Hartmann, KW Jauch, HJ Schlitt, TS Weiss · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
ALR (Augmenter of Liver Regeneration) a member of the hepatotrophic growth factors was found to be essential cellular growth and to have specific liver regeneration enhancing effects. Further it was proposed that ALR might act through auto- and paracrine mechanism during liver cell proliferation, but little is known about its expression in normal and cirrhotic or cancerous human liver tissue. Expression analysis of ALR was performed by immunohistochemistry on paraffin sections of human normal liver tissue (n=43), cirrhotic livers (n=66) and hepatocellular carcinomas (HCC) (n=137) with various underlying diseases…
