CareLit Fachartikel
Transcriptional activity of iron homeostasis maintaining genes in HCV infection
S Mihm, F Moriconi, G Ramadori · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Dokument
1043727
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Zusammenfassung
Background and Objectives: In chronic hepatitis C, hepatic iron content is mildly elevated. An excess of hepatocyte iron is currently discussed as a cofactor for the development of HCC. The mechanisms leading to iron overload are not yet understood and may range simply from an iron shift from serum to tissue as it occurs e.g. in bacterial infections to a dysregulation of the complex iron homeostasis. To address this issue, we quantified the expression of several genes that are involved in iron metabolism both in liver tissue from chronic hepatitis C patients and in human Huh–7 hepatoma cells harbouring HCV repli…
Schlagworte
hepatitis C
iron
Hepatitis
Bacterial Infections
Cytokine
Address
Actin
Zeitschrift für Gastroenterologie
