Adiponectin as a modulator of hepatic fibrosis in chronic HCV-Infection
I Wedemeyer, K Petmecky, U Drebber, E Kühnen, S Mohren, R Weiskirchen, A Canbay, M Odenthal, HP Dienes · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Adiponectin is a member of adipose tissue-secreted hormones, so-called adipokines, and has wide implications in glucose and lipid metabolism. It is also found in liver tissue and in NAFLD/NASH it provides protective features on liver tissue like antiinflammatory and antifibrotic effects. There are two specific receptors for adiponectin: AdipoR1 with abundant expression and AdipoR2 with expression especially on hepatocytes. Yet, little is known about the role of adiponectin in chronic HCV-infection. Recently, genetic studies of single nucleotide polymorphisms (SNP) of the adiponectin gene, e.g. +276G>T, have show…
