Heparanase and hVEGF165, increases early engraftment, intravascular survival and endothelial cell proliferation, of transplanted hepatocyte, in hepatectomized rats
Y Baruch, I Boyanjo, V Tsiperson, Y Axelman, J Dudas, G Ramadori, N Ilan, G Shoshany, I Vlodavsky, E Veitzman · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Heparanase by degradating heparan sulfate proteoglycans has multifunctional effect on cell-cell interaction, cell invasion and angiogenesis. VEGF, a potent angiogenic factor promotes hepatocyte growth, increases vascular permeability and vasodilatation, and may thus accelerate cell engraftment Aim: The effect of heparanase and hVEGF165, on hepatocyte engraftment after intrasplenic cell transplantation in partially hepatectomized (PHP) rats. Methods: Female Lewis rats were subjected to 70% PHP and transplanted with male hepatocytes (107 cells/rat), pre- incubated with heparanase (50µl, n=12), or 240ng VEGF165 or…
