CareLit Fachartikel

Identification of candidate genes that mediate depressive side effects of pegylated IFN-α2a in patients with chronic hepatitis C

M Trippler, Y Erim, S Bein, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1043731
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Trippler, Y Erim, S Bein, G Gerken, JF Schlaak
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967915

Zusammenfassung

Aims and background: Combination therapy with pegylated interferon IFN-α plus ribavirin has been shown to be the most effective treatment for chronic hepatitis C (HCV). One of the most common side effects is IFN-induced severe depression, which can impair quality of life, reduce treatment adherence and even lead to suicide. Therefore, defining relevant risk factors for IFN-α induced depression is essential for designing preventative treatment strategies. This study assessed the primary transcriptional response to IFN-α2a plus ribavirin in HCV patients to identify possible candidate genes that mediate the depress…

Schlagworte

Depression Lead Hepatitis After Anxiety Blood Axis Zeitschrift für Gastroenterologie