Influence of gastric acid inhibition with Esomeprazol concerning length of Barrett's Esophagus without evidence of intraepithelial neoplasia

Introduction: The goals of treatment in fBarrett's esophagus are to eliminate symptoms of reflux disease and reverse the metaplastic mucosa. The purpose of this prospective randomiezed double blinded study was to assess the efficacy of high dose treatment with esomeprazole vs. placebo on symptoms relief and regression of Barrett's esophagus after 6 months of therapy. Only targeted biopsies after acetic acid magnification chromoendoscopy or confocal endomicroscopy were performed. Furthermore for the first time a catheter with units of measurement were used to determine exactly and reproducible the length of the c…