Secretory products from human adipocytes impair endothelial function via nuclear factor κ B
S Kralisch, G Sommer, V Stangl, U Köhler, J Kratzsch, H Stepan, R Faber, A Schubert, U Lössner, A Vietzke, M Blüher, M Stumvoll, M Fasshauer · Diabetologie und Stoffwechsel · 2007 · Heft 08
Bibliografische Angaben
Zusammenfassung
Hyperplasia and hypertrophy of fat cells can be found in obesity and increased adiposity is associated with endothelial dysfunction as an early event of atherosclerosis. However, it is unclear whether human adipocytes directly influence endothelial function. To study the crosstalk between fat and endothelial cells, human umbilical venous endothelial cells (HUVECs) were cultured in infranatants (Adipo) of primary differentiated human adipocytes. Interestingly, incubation of HUVECs with Adipo significantly increased monocyte adhesion 7.3-fold as compared to control conditions. VCAM-1, ICAM-1, and E-selectin were u…
