The ATP-binding cassette transporter ABCG2 (BCRP) and ABCB1 (MDR1) variants are not associated with disease susceptibility and disease phenotype in Hungarian patients with inflamm…
S Fischer, L Lakatos, A Kovacs, T Molnar, I Altorjay, M Papp, Z Tulassay, J Osztovits, P Demeter, A Tordai, H Andrikovics, J Papp, PL Lakatos · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: MDR1 (ABCB1), a member of the ATP-binding cassette (ABC) transporters, is an attractive candidate gene for the pathogenesis of inflammatory bowel diseases (IBD) and perhaps response to therapy. Since limited data are available on MDR1 and ABCG2 polymorphisms in East European IBD patients, our aim was to study the ABCG2 and MDR1 variants and patients' response to medical therapy and/or disease phenotype in Hungarian patients. Methods: 414 unrelated IBD patients (CD: 265, age: 35.2±12.1years, duration: 8.7±7.6years and UC:149, age: 44.4±15.4 years, duration: 10.7±8.9 years) and 149 healthy subjects were inve…
