A case of primary biliary cirrhosis (a problem of differential diagnosis?)

Introduction: The diagnosis of primary biliary cirrhosis (PBC), a chronic cholestatic disorder of the liver, is one of exclusion. The autoimmune pathogenesis of PBC is characterized by inflammatory damage and a progressive destruction of bile ducts, which leads to fibrosis, and finally cirrhosis. A hallmark for the diagnosis of PBC is the presence of antimitochondrial antibodies (AMA) in serum. Genetic predisposition plays role in pathognomic antibody production, although it means influences the prognosis, rather than the predisposition. Case report: Elevated levels of liver enzymes (GOT: 81U/l, GPT: 92U/l, GGT:…