Effects of calcium antagonists on insulin secretion

Aim Citolic calcium levels influence glucose-stimulated insulin secretion. In vitro studies have shown that calcium antagonists can inhibit insulin secretion and thus to alter glucose metabolism. The aim of our work was to study if long-term calcium-antagonists treatment alters insulin secretion in vivo. Patients and Methods Two groups of essentiai hypertensive patients were studied: one with obesity (n=18) and the other one without obesity (n=8). All of the patients had normoglucose tolerance and no family history of diabetes mellitus. All patients underwent a frequently sampled intravenous glucose tolerance te…