Long-term complications costs for type 1 diabetes patients on detemir versus NPH-based basal-bolus therapy in a german setting. A modelling evaluation based on results from a meta…

Aim: To evaluate lifetime costs associated with complications in type 1 diabetes patients treated with either insulin detemir (IDet) or human insulin (NPH) based basal-bolus therapy in a German setting. Methods: A published and validated computer simulation model was used to project the long-term progression of diabetes-related complications based on probabilities from landmark clinical and epidemiological studies and account associated costs. Clinical effects of treatment were obtained from a meta-analyses of three clinical trials demonstrating reductions in HbA1c (-0.13%), body mass index (BMI) (0.21kg.m-2) fo…