Brain endothelial PPAR-gamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro

An important step in the pathogenesis of multiple sclerosis is the adhesion and subsequent transmigration of activated encephalitogenic CD4+ T cells across highly specialized endothelial cells (EC) participating in the formation of the blood-brain-barrier. Recruitment of CD4+ T cells across brain EC relies on interaction with EC-expressed adhesion molecules that allow immune surveillance of the CNS, but also promote CNS invasion by encephalitogenic T cells under inflammatory conditions. Our results provide molecular evidence that the transcription factor peroxisome proliferator-activated receptor gamma (PPARg) i…