Efficacy and safety of pregabalin for trigeminal neuralgia: prospective observational study

Objectives: Trigeminal neuralgia is the most common craniofacial pain syndrome of neuropathic origin. Patients often suffer from concomitant sleep and/or mood disorders which additionally affect their quality of life and functional status. Pregabalin is approved for, among other indications, the treatment of peripheral and central neuropathic pain (NeP). It binds with high affinity to the alpha2-delta subunit protein of voltage-gated calcium channels and, thereby, reduces release of excitatory neurotransmitters. We aimed to assess the efficacy and safety of twice-daily flexible-dose pregabalin (mean: 301mg/d) in…