Severe acute granulomatous myositis and fasciitis in graft-versus-host disease

Polymyositis associated with chronic graft-versus-host disease (GVHD occurs in 3–7% of patients after allogeneic hematopoietic stem cell transplantation (HSCT). The few reported cases with acute onset of polymyositis are mainly related to donor lymphocyte infusion (DLI). Fasciitis along with other manifestations of GVHD has been obeserved in 3% of allogeneic HSTC patients. We report a 58-year-old man, who was diagnosed with chronic idiopathic myelofibrosis (CIMF) and associated anemia in July 2002 and received allogeneic HSCT from his HLA-identical brother in December 2005. Three months later immunosuppressive t…