Adult neurogenesis in Parkinson's disease

Introduction and aim: Different acute and chronic experimental models mimick certain pathological hallmarks associated with Parkinson's disease (PD): while lesion models induce selectively a dopaminergic deficit in the nigrostriatal system, transgenic models lead to an accumulation of alpha-synuclein. In alpha-synuclein models wild-type alpha-synuclein accumulates during aging, whereas alpha-synuclein mutations (e.g. A53T) lead to an earlier onset as well as a more severe course of the disease. Accumulation of alpha-synuclein in the forebrain as well as in the olfactory bulb is particularly of clinical relevance…