Profibrogenic TGF-beta/ALK5 signaling via CTGF expression in hepatocytes
HL Weng, L Ciuclan, J Hamzavi, P Godoy, Y Liu, E Ueberham, R Gebhardt, S Kanzler, R Heuchel, K Breitkopf, S Dooley · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Connective Tissue Growth Factor (CTGF) plays an important role in TGF-β induced liver fibrogenesis. Hepatic stellate cells and bile duct epithelial cells were recognized as its cellular source in liver. Here, we demonstrate induction of CTGF expression in hepatocytes of damaged liver and identify a molecular mechanism responsible. Strong CTGF expression was found in bile duct epithelial cells, hepatic stellate cells and hepatocytes in fibrotic liver tissue from patients with chronic hepatitis B infection. Similarly, CTGF expression was induced in hepatocytes of CCl4 treated FVB mice. CTGF expression and secretio…
