Local grading of inflammation in chronic Inflammatory Bowel Disease (IBD) by dynamic tissue perfusion measurement (PixelFlux-method)

Objectives: The novel method of dynamic tissue perfusion measurement in color Doppler sonographic videos was applied to sonographic inflammation grading in IBD (Crohn disease [CD] and ulcerative colitis [UC]) as well as to healthy probands to evaluate the potential of the new method compared to established inflammation grading techniques. Methods: Perfusion intensity was measured by the PixelFlux-method (www.chameleon-software.de) in standardized DICOM video clips of the intestinal wall in 34 healthy subjects (5–18 years), 14 CD patients (8–16 years) and 19 UC (12–18 years) patients under defined and constant co…