Indications for nodal irradiation in breast cancer patients

Carcinoma of the breast is the most frequent malignancy in women. Based on the results of the Danish and British Columbian trials postoperative local irradiation was considered mandatory and is a well established management now. At present, there is no general agreement on the necessity of regional nodal irradiation after breast conserving surgery or modified radical mastectomy. Advances in early breast cancer management have led to the necessity of ongoing evaluation of the optimal adjuvant locoregional treatment. For breast carcinoma, involvement of the axillary lymph nodes is the single most important prognos…